Latest News:

Jason Adelman, MD, Medicine, will receive $646,403 over five years from the Agency for Healthcare Research and Quality for “Preventing Wrong-Drug and Wrong-Patient Errors With Indication Alerts in CPOE Systems.”

Wellington Cardoso, MD, PhD, Medicine, will receive $6,704,064 over seven years from the National Heart, Lung, and Blood Institute for “Mechanisms Controlling Expansion and Lineage Specification of Airway Progenitors in Development and Disease.”

Keith Diaz, PhD, Medicine, will receive $2,687,358 over four years from the National Heart, Lung, and Blood Institute for “Impact of Prolonged Sedentary Behavior on Cardiac Outcomes and Mortality in Acute Coronary Syndrome Patients.”

Henry Ginsberg, MD, Medicine, will receive $6,677,174 over seven years from the National Heart, Lung, and Blood Institute for “Phenotyping Genetic Disorders of Hepatic Lipid and Lipoprotein Metabolism in Cells, Mice, and Men.”

Dawn Hershman, MD, Herbert Irving Comprehensive Cancer Center, will receive $375,000 over one year from the Avon Foundation for “Breast Cancer Access to Care and Disparities Research Program” in a competitive renewal.

Steven J. Shea, MD, Medicine, will receive $300,980 over four years from the National Heart, Lung, and Blood Institute for “Individual Response to Vitamin D Treatment.”

Hans-Willem Snoeck, MD, PhD, Medicine, will receive $1,800,852 over four years from the National Heart, Lung, and Blood Institute for “Mitochondrial Regulation of Hematopoietic Stem Cells.”

Timothy Cragin Wang, MD, Medicine, will receive $6,414,000 over seven years from the National Cancer Institute for “The Role of Stem Cells and the Microenvironment in Gastrointestinal Cancers.”

Provost Leadership Fellows Program

  • The Provost Leadership Fellows Program is designed for faculty members at Columbia who seek to complement their research and scholarly activities with administrative and leadership responsibilities. Six CUMC faculty members were selected for the current cohort, and Ali Gharavi, MD, Chief of Nephrology represents Medicine

Natalie Bello, MD, Medicine, received the American College of Cardiology/William F. Keating Esq. Endowment Career Development Award for “Home Blood Pressure Monitoring and Hypertension in Pregnancy.”

Matthew Lewis, MD, Medicine, received an honorable mention for the Young Investigator Awards in Basic and Translation Science presented by the American College of Cardiology.

Muredach Reilly, MBBCh, and Marwah Abdalla, MD, Medicine, have been named 2017 Marjorie and Lewis Katz Scholars for their contributions to the field of cardiovascular research.

Gary Schwartz, MD, Medicine, will receive the Nobility in Science Award from the Sarcoma Foundation of America at its annual gala in April. This award, the foundation’s highest honor, is given “to an outstanding scientist who is dedicated to the advancement of knowledge of sarcoma and works tirelessly to find innovative approaches for treating it.”

Emily Tsai, MD, Medicine, received the American College of Cardiology Presidential Career Development Award for “Therapeutic Potential of Myocardial Soluble Guanylyl Cyclase Stimulation in Right Ventricular Dysfunction: Microdomains of Novel Cardioprotective cGMP Signaling Mechanisms.”

Sunday Routine (New York Times)
How Dr. Siddhartha Mukherjee, Cancer Expert, Spends His Sundays
Working as a cancer physician, researcher and assistant professor at Columbia University doesn't seem to be enough action for Dr. Siddhartha...

New York Times
Henry S. Lodge, Author of 'Younger Next Year' Books, Dies at 58
Dr. Henry S. Lodge, whose series of health-advice books, “Younger Next Year,” written with his patient Chris Crowley, sold in the millions, died on...

Book Review (New York Times)
The Future of Humans? One Forecaster Calls for Obsolescence
Editor's Note: Siddhartha Mukherjee is an assistant professor of medicine at Columbia University.

Sunday Morning (CBS News)
A history of cancer
Editor's Note: Siddhartha Mukherjee and anchor Jane Pauley discuss the milestones in cancer's history and the breakthroughs in mankind's attempt to...

Medical News
Study finds only 16% of heart attack survivors get recommended amount of physical activity
"Researchers and clinicians need to find ways of getting more people to participate in such supervised exercise programs," Dr. [Ian] Kronish said.

6 colon cancer warning signs never to ignore
Probably the most common warning sign is rectal bleeding, said Dr. Alfred Neugut, a medical oncologist and cancer epidemiologist at the Columbia...

Huffington Post
History Of Women's Heart Health Movement Is Her Story, Too
Laboratories at five institutions are studying different aspects; Columbia University is one such center – under the direction of Lori Mosca, of...

Medical Xpress
Kidney damage diagnosis may be inaccurate for many, suggests study
In a related Comment published today in The Lancet, Jonathan Barasch, MD, PhD, professor of medicine and pathology and cell biology at CUMC, and...

USA Today
Column: The best medicine doctors don't tell you about
Editor's Note: Shilpa Ravella, MD is an assistant professor of medicine at Columbia University Medical Center.

Voice of America
HIV: Turning the Corner
Editor's Note: Jessica Justman, of the Mailman School, discusses the success of PEPFAR in three African countries.

Huffington Post
Helping doctors to care
Editor's Note: Craig Blinderman is the director of the Adult Palliative Care Service at Columbia University Medical Center.

Science of Us (New York Magazine)
Scientists Can Tell If You're Eating Healthy by Studying Your Pee
Editor's Note: Shilpa Ravella is an assistant professor of medicine at Columbia University Medical Center.

Wall Street Journal
A 'Spiritual Board' Brings Comfort to the Critically Ill
Matthew Baldwin, a critical care physician at NewYork-Presbyterian/Columbia University Medical Center, led a study with Chaplain Joel...

MSNAPS: Michael Brecker memorial concert
Crain's New York (requires a subscription)

Editor's Note: Fashion designer Donna Karan joined Dr. Azra Raza, director of Columbia's Myelodysplastic Syndrome Center, at the fundraiser.

Manhattan Times
13 Heart to Heart Facts
Editor's Note: Jennifer Haythe is a cardiologist and an assistant professor of medicine at Columbia University Medical Center.

Huffington Post
Here's What Happens When You Give Psychedelic Drugs To Spiritual Leaders
Dr. Craig Blinderman, director of adult palliative care services at Columbia University Medical Center/New York-Presbyterian Hospital, said the...

Botox for fighting cancer?
August 25, 2014
Botox is commonly used to deaden the nerves of the face, paralyzing tiny muscles to smooth wrinkled skin. But it has other medical uses, including fighting migraines, muscle spasms, and excessive sweating. The toxin fades after about four months, enough time to make the cancer cells more sensitive to blasts of chemotherapy, said Timothy Wang, a coauthor of the paper and chief of the Division of Digestion and Liver Diseases at Columbia University.

Botox blitz could work against stomach cancers
August 22, 2014
One method for treating stomach cancer is to sever the branches of the vagus nerve that innervate the stomach, a procedure known as a vagotomy. That's because the nervous system influences how certain cells behave, in some cases encouraging tumour growth. But a vagotomy is a very invasive procedure. Timothy Wang of Columbia University, New York, and his colleagues wondered whether the same effect could be achieved with a drug.

Botox could be injected to beat stomach cancer
August 21, 2014
Timothy Wang, professor of medicine at Columbia University Cancer Centre, said: “Over-activity of nerves in the stomach could promote abnormal growth. We found that blocking the nerve signals makes the cancer cells more vulnerable.”

Botox may have cancer fighting role
August 20, 2014
One of the scientists, Dr Timothy Wang, told the BBC: "If you just cut nerves is it going to cure cancer? Probably not. At least in early phase, if you [disrupt the nerve] the tumour becomes much more responsive to chemotherapy, so we don't see this as a single cure, but making current and future treatments more effective."

Botox Tested on Stomach Cancer in Mice
August 20, 2014
"The nerves are silenced or muted, unable to signal to the stem cells and cancer stem cells in the stomach," said study co-author Dr. Timothy Wang, professor of medicine and chief of digestive and liver diseases at Columbia University Medical Center in New York City. According to the study, the two treatments reduced the number of tumors and their progression while boosting survival and the effects of chemotherapy.

Consumer Reports
Don't reach for the butter and bacon just yet
April 11, 2014
“Dietary research is some of the hardest to conduct,” said David S. Seres, M.D., a member of Consumer Reports medical advisory board and director of medical nutrition and associate professor of medicine at Columbia University College of Physicians and Surgeons. “While this study supports my own bias that we are far from really knowing what to recommend, it is difficult to conclude from it that we should make any changes in the dietary guidelines.”

Capital New York
Capital Health Care: ‘N-bomb’ ban, and Koch Industries' Obamacare payout
April 09, 2014
MAKING ROUNDS -- Dr. Ali G. Gharavi is the new chief of the division of nephrology at NewYork-Presbyterian/Columbia University Medical Center. Gharavi is interested in the genetics of kidney disease, including IgA nephropathy and congenital abnormalities of the kidney and urinary tract.

Cardiovascular Business
Patients with PTSD less likely to take hypertension meds
December 04, 2013
Researchers led by Ian M. Kronish, MD, MPH, of Columbia University Medical Center in New York City, studied 98 patients with uncontrolled hypertension...

CNN Health
Can you OD on caffeine?
December 03, 2013
"Safe doses of caffeine are usually quoted at around 200 to 300 milligrams, or two to four cups of coffee per day," says Dr. David Seres, associate professor of clinical medicine at Columbia University.

Medpage Today
PTSD Patients Likely to Skip BP Meds
December 02, 2013
In a small study, 68% of hypertensive patients with positive screening results for PTSD ..., according to Ian Kronish, MD, MPH, of Columbia University in New York City, and colleagues.

Voice of America
Scientists Grow Lung Cells from Stem Cells
December 02, 2013 leader Hans-Willem Snoeck, MD, PhD, of the Columbia University Medical Center. Snoeck added that lung transplants have a particularly poor...

ABC News 4
Chelation Therapy Reduces Cardiovascular Events For Older Patients With Diabetes
November 19, 2013
...please contact SOURCE Mount Sinai MedicalCenter /PRNewswire-USNewswire/ -- Chelation treatments reduce cardiovascular...
..."These are striking results that, if supported by future research, could point the way towards new treatments to prevent complications of diabetes," said Gervasio A. Lamas, M.D., the study's principal investigator and chairman of medicine and chief of the Columbia University Division of Cardiology at Mount Sinai Medical Center in Miami Beach, Fla. 

Type 1 diabetes and heart disease linked by inflammatory protein
May 7, 2013
Type 1 (insulin-dependent) diabetes appears to increase the risk of heart disease, the leading cause of death among people with high blood sugar, partly by stimulating the production of calprotectin, a protein that sparks an inflammatory process that fuels the buildup of artery-clogging plaque. The findings, made in mice and confirmed with human data, suggest new therapeutic targets for reducing heart disease in people with type 1 diabetes... Scientists have known that diabetes leads to atherosclerosis. The study shows that this is associated with increased circulating levels of inflammatory white blood cells (WBCs), which contribute to the build-up of plaque. "But exactly how diabetes causes white blood cells to proliferate and lead to heart disease has been a mystery," said study co-leader Ira J. Goldberg, MD, Dickinson W. Richards Professor of Medicine at CUMC.


Living Beyond Breast Cancer Announces Conference Details
May 1, 2013
Living Beyond Breast Cancer (LBBC) announced today that The New York Times best-selling author, Siddhartha Mukherjee, MD, will open its fall conference, "News You Can Use: Breast Cancer Updates for Living Well," with a lecture on Saturday, October 26 at the DoubleTree by Hilton Hotel Philadelphia Center City. LBBC CEO Jean Sachs, MSS, MLSP, also reported that the national nonprofit organization's annual event will expand with an additional half day of educational programming and interactive workshops on Sunday, October 27.

Study Debunks Lyme Disease-Autism Link By Serena Gordon
April 30, 2013
A new study failed to find any evidence to back up a suggested association between Lyme disease and autism spectrum disorders. ..."Unless a child has been diagnosed with Lyme disease or another infectious disease, our findings don't support the idea of putting autistic children on antibiotics," said study senior author Armin Alaedini, an assistant professor of medical sciences in the department of medicine and the Institute of Human Nutrition at Columbia University Medical Center, in New York City. Results of the study appear in the May 1 issue of the Journal of the American Medical Association.


Lyme Disease, Autism Link Debunked By Charlene Laino
April 30, 2013
A new study has found no evidence of an association between Lyme disease and autism. "While a proposed link between Lyme disease and autism has garnered considerable attention over the past 2 years, none of the 70 children with autism or 50 unaffected controls in our study had serological evidence of Lyme disease by CDC-recommended two-tier testing," said corresponding author Armin Alaedini, PhD, of Columbia University Medical Center in New York City.


Daily Dish
World's largest gluten-free expo: Samples, cooking demos, beer and more By Jenn Harris
April 30, 2013
Those following a gluten-free diet will want to leave Sunday open. The world's largest gluten-free expo is coming to the Pasadena Convention Center. ...Those wanting to learn more about gluten sensitivity can register to attend a national education conference to be held Saturday at the Pasadena Convention Center. Drs. Joseph Murray of the Mayo Clinic and Peter H.R. Green of the Celiac Disease Center at Columbia University are scheduled to speak.

Blog: Shots
Failure Of Latest HIV Vaccine Test: A 'Huge Disappointment' By Richard Knox
April 26, 2013
The largest current study of an AIDS vaccine, involving 2,500 people, is being stopped. After an oversight committee took a preliminary peek at the results this past Monday, they concluded there was no way the study would show that the vaccine prevents HIV infection... "It was a huge disappointment," says study leader Dr. Scott Hammer, who learned the bad news at 1:45 Monday afternoon. "It was a big traumatic event to put all this effort in and then have the vaccine trial stop because of futility a month after we completed enrollment," Hammer says. He's chief of infectious diseases at Columbia University College of Physicians and Surgeons and a leading AIDS researcher who's been fighting the virus since the pandemic's beginning... This latest bad news "will throw the field into another round of discussion" about what to do next, Hammer says. What it will not do, he says, is reduce the drive to keep trying until scientists come up with a vaccine "that gives us solid protection" against multiple strains of HIV. "That will be a very joyous day."

HIV vaccine trial shut down By Melissa Healy
April 25, 2013
In another major setback for efforts to develop an HIV vaccine, federal researchers have shut down a key clinical trial after an independent panel of safety experts determined that volunteers who got an experimental vaccine appeared to be slightly more likely to contract the human immunodeficiency virus than those who got a placebo... "This is quite a substantial disappointment," said Dr. Scott Hammer, a Columbia University virologist who is one of the trial's principal investigators. But, Hammer added, "we've learned from every clinical efficacy trial we've done. We've had good and bad news, but each one takes us a little closer in terms of what to pursue and not to pursue."

Breath Test Might Predict Obesity Risk By Denise Mann
March 26, 2013
A simple breath test may be able to tell if you are overweight or will be in the future, a new study suggests.
According to the findings, results from a standard breath test used to assess bacterial overgrowth in the gut can also tell doctors if you have a high percentage of body fat. ...It's way too soon to start thinking about probiotics as a treatment for obesity, said Dr. Peter Green, director of the Celiac Disease Center at Columbia University Medical Center, in New York City. "Some people with bacterial overgrowth in their gut have symptoms, but others do not and we are not sure why. The significance of the test results is not always quite clear," he said.


50 Women Who Shaped America's Health
March 18, 2013
Dr. Virginia Apgar, M.D., (born in 1909, and died in 1974) is best known for developing a standardized system to evaluate the health of babies when they are born. Apgar was also the first woman to earn the title of full professor at the College of Physicians and Surgeons at Columbia University, in the year 1949.

Wafaa El-Sadr has spent her career on the underserved populations -- from the inner city to sub-Saharan Africa -- that require greater attention when it comes to preventing infectious disease. As head of ICAP, El-Sadr has helped an estimated 1,000,000 HIV patients to receive the services they need and has helped 500,000 patients access the anti-retroviral treatment they require.

Geneticist and Higgins Professor of Neuropsychology at Columbia University, Nancy Wexler, Ph.D. is most well-known for her research surrounding Huntington's Disease, a genetic condition that causes parts of the brain to degenerate. Wexler's study of the world's largest family with the disease has led to identifying the gene responsible for Huntington's.

Picked up by TOTAL E-CLIPS.

Centralized, Stepped, Patient Preference–Based Treatment for Patients With Post–Acute Coronary Syndrome Depression
March 15, 2013 Interview with Karina W. Davidson, PhD, Center for Behavioral Cardiovascular Health, Department of Medicine, Columbia University Medical Center, New York, New York

“We tried to help them really think through what does it take to take a pill every day; what does it take to talk to a person about painful feelings and do homework, and really consider what will fit into their life,” said Dr. Davidson. “And every six to eight weeks, we revisited how their chosen treatment was working for them, and helped them make adjustments based upon their feedback.”

Leading in service, science and heart By Sherry Mazzocchi
March 6, 2013
On the eve of the 159th anniversary of the of the Dominican Republic’s Independence Day, political and community leaders paid homage to a long-time citizen and supporter of the Washington Heights’ Dominican community. Nearly 200 people gathered at the Isabella Geriatric Center to honor Dr. Rafael Lantigua this past Tues., Feb. 26th. ...He told the audience that of the 170 spots offered to incoming students at Columbia University Medical College, 25 of them would go to Dominicans. They are coming from schools such as Stanford, Princeton and Yale. “And five of them,” he said, “are from Washington Heights.”

CPR more often prolongs seniors' suffering than saves lives By Paul C. McLean
March 5, 2013
In the Journal of the American Medical Association in March 2012, physicians Craig Blinderman of Columbia University Medical Center and Eric Krakauer of Massachusetts General Hospital, with social scientist/bioethicist Mildred Solomon of the Hastings Center, suggested that CPR should no longer be the default option for dying patients: "Whenever there is a reasonable chance that the benefits of CPR might outweigh its harms, CPR should be the default option. However, in imminently dying patients, a default status of full resuscitation is not justifiable.”

Blacks and Hispanics at Higher Risk for Precancerous Colorectal Polyps
March 4, 2013
Blacks and Hispanics have a significantly higher risk of developing precancerous colorectal polyps compared with whites, according to a study by researchers at NewYork – Presbyterian Hospital/Columbia University Medical Center. The findings appeared in the online edition of Alimentary Pharmacology and Therapeutics. “Our data suggest that we need to redouble our efforts to increase colon cancer screening in areas with large numbers of racial and ethnic minorities,” said lead author Benjamin Lebwohl, MD, MS, assistant professor of clinical medicine and epidemiology at NewYork – Presbyterian Hospital/Columbia University Medical Center and Columbia University’s Mailman School of Public Health.

Stages of COPD By Gina Roberts-Grey
March 4, 2013
Depending on how advanced your condition is, your doctor may advise you to use a short-acting bronchodilator, like prescription COPD medications Symbicort or Spiriva, or inhaled corticosteroids to manage symptoms of COPD. ...But if you’ve kicked the habit and take your medicines (like bronchodilators and inhaled corticosteroids), your symptoms of COPD may not get worse, says Byron Thomashow, M.D., medical director at Columbia University/New York Presbyterian Hospital. “Once you’re on medicine and possibly receiving pulmonary rehabilitation, you should be able to do everyday things, like grocery shop, take a walk and play catch with grandkids,” says Thomashow.

Finances, satisfaction grow as Mount Sinai Medical Center enjoys winning streak By Mike Seemuth
March 3, 2013
Moving into 2013, management at this not-for-profit medical center expects yet another profitable year. Among other reasons for bottom-line optimism, a $135 million bond refinancing last summer has produced annual savings of $1.5 million... Key were a partnership with New York’s Columbia University and the recruitment of Dr. Joseph Lamelas, a pioneer in minimally invasive heart valve surgery. He joined Mount Sinai in 2008 as chief of cardiac surgery and has become a feature attraction at the hospital. “He is the best cardiac surgeon, in my opinion, in the state of Florida, for sure, and probably in the Southeast,” said Dr. Gervasio Lamas, chief of the Columbia University Division of Cardiology at Mount Sinai. ...Mount Sinai’s educational side has gained from the hospital’s three-year-old relationship with Columbia University, which has research-driven affiliations with Mount Sinai Medical Center. Mount Sinai has “a very comprehensive academic program even if they are not themselves a medical school,” said Doug Levy, a spokesman for Columbia’s medical school. “We’re able to provide additional training and outreach to the physicians there, and we also benefit from what they’re learning from their patient populations. So it’s a two-way information flow. It certainly facilitates research collaboration.”

This Morning
Widely used chemical linked to childhood asthma
March 2, 2013
BPA has been linked to behavior problems, obesity, hormone abnormalities and even kidney and heart problems. Now, new research from scientists at the Columbia Center for Children's Environmental Health has found a link between the compound and an increased risk for asthma. "Our study found that routine low doses of exposure were associated with increased odds of wheezing," said lead author Dr. Kathleen Donohue, an assistant professor of medicine at Columbia University College of Physicians and Surgeons and an investigator at the center.

BPA exposure may raise child's asthma risk By Ryan Jaslow
March 1, 2013
Asthma rates climb in the United States every year, and a new study suggests exposure to the chemical BPA may be a reason. ..."Asthma prevalence has increased dramatically over the past 30 years, which suggests that some as-yet-undiscovered environmental exposures may be implicated," explained study author Dr. Kathleen Donohue, an assistant professor of Medicine at Columbia University College of Physicians and Surgeons and an investigator at the Center for Children's Environmental Health, in a press release. "Our study indicates that one such exposure may be BPA."

The Chart
Study finds link between BPA and asthma By Stephanie Smith
March 1, 2013
The list of maladies linked to the chemical is growing longer. The latest study, by researchers at the Columbia Center for Children's Environmental Health, suggests a possible connection between BPA detected in urine samples of children and later problems with breathing. ... "What is important is that we were seeing the association at routine low doses of exposure," said Dr. Kathleen Donohue, the lead study author.

Also picked up by RODALE NEWS.

Blog: Science Speaks
Physicians call for research on ART initiation, Urging lawmakers to fund AIDS-free generation, and more
By Rabita Aziz
February 21, 2013
When to Start in Africa – An Urgent Research Priority: In this opinion piece in the New England Journal of Medicine, Dr. Kevin de Cock, Director of the CDC’s Center for Global Health, and Dr. Wafaa El-Sadr, member of IDSA’s Center for Global Health Scientific Advisory Committee, make a strong case for more research to determine the best time to initiate ART in African patients. Citing a lack of conclusive data to back ART initiation guidelines, De Cock and El-Sadr call for a randomized, controlled trial to determine when to initiate ART in Africa for maximal individual health benefit.

Is A Gluten-Free Diet Healthy For Those Without A Sensitivity To Wheat?
By Erin Billups
February 18, 2013
Gfreely offers suggestions on how to live wheat-free and sells an assortment of products like Kale chips, made by NY Naturals in a Brooklyn factory. Already, it has nearly 1,000 customers, speaking to what Dr. Peter Green, director at Columbia University's Celiac Disease Center, calls a worldwide phenomenon.
...Dr. Green says that those who feel better after cutting wheat out of their diet are gluten-sensitive, and may very well have Celiac, an autoimmune disorder where the body has a destructive reaction to gluten. For them, cutting out gluten is essential. But for those who are not gluten-sensitive, the diet could become unhealthy.

This Morning
A Doctor’s Note
February 16, 2013
An emergency room doctor took the time to write a heartfelt letter to the husband of a woman who died while in his care and that gesture has inspired millions. Dr. Jon Lapook, CBS News Medical Correspondent and Columbia Clinical Professor of Medicine, tells us why letters like this are so rare.

Crowded Emergency Rooms Linked to PTSD in Chest Patients By Shannon Pettypiece
February 12, 2013
Chaotic, overcrowded emergency rooms may cause some heart patients to develop post-traumatic stress disorder … according to a report released yesterday in JAMA Internal Medicine. PTSD occurs in about 12 percent of heart attack patients and has been found to double their risk of dying over the next one to three years, said Donald Edmondson, a researcher on the study and assistant professor at Columbia University whose research focuses on the behavioral effects of disease. … “A heart attack is in and of itself a life-threatening terrifying event, your body has turned against you, and you don’t know if you’re going to live through this thing,” said Edmondson in an interview. “An overcrowded ER can exacerbate that.”


Hospital environment tied to PTSD in heart patients: study By Andrew Seaman
February 12, 2013
Being treated for a heart attack in a crowded emergency department may be linked to developing symptoms of post-traumatic stress disorder (PTSD), according to a U.S. study. ..."What we're showing here is - aside from the severity of a heart attack - the emergency department itself can carry forward and impact a person's psychological adjustment after," said lead author Donald Edmondson, from Columbia University Medical Center in New York.




Domenico Accili, MD, Medicine, received $1.6 million from the PB Foundation for “Beta Cell Differentiation as a Diabetes Treatment.”

William S. Blaner, PhD, Medicine, received $420,000 through November 2014 from the National Institute on Alcohol Abuse and Alcoholism for “Alcohol Consumption and Brown Adipose Tissue.”

Herbert Chase, MD, Medicine, received $302,726 through July 2013 from the New York State Office of Science, Technology, and Academic Research for “Timely Training of Workers Competent to Support HER Deployment and Meaningful Use.”

Rudolph L. Leibel, MD, Pediatrics and Medicine, received $298,345 through May 2013 from the Leona M. and Harry B. Helmsley Charitable Trust for “Understanding the Molecular Pathogenesis of Beta Cell Failure in Diabetes.”

Timothy C. Wang, MD, Medicine, received $994,065 over five years from the Massachusetts Institute of Technology for “GI Tract Dysbiosis and Breast Cancer.”

Stephen G. Emerson
, MD, PhD, Medicine, was awarded the Légion d’Honneur by the French Ambassador François Delattre for returning to the Institut de France an original letter by René Descartes, written in 1641.

Uptal B. Pajvani, MD, PhD, Medicine, received $60,000 from the Edward Mallinckrodt Jr. Foundation to cover the first year of research on his study of how notch regulates hepatic glucose and lipid metabolism.

Elizabeth Shane, MD, Medicine, was named CUMC Mentor of the Year by the Office of Academic Affairs and the Irving Institute for Clinical and Translational Research.

As part of its mission to transform the culture of biomedical research, accelerate the discovery of new treatments, and train the next generation of research investigators, the Irving Institute for Clinical and Translational Research, home to Columbia University’s Clinical and Translational Science Award (CTSA), funds pilot programs and career development initiatives. The Irving Institute is proud to announce the selection of award recipients for the following programs:

A two-phase program that provides planning and start-up funds to newly configured, multidisciplinary investigative teams to support the planning of novel, multidisciplinary projects. The four recipients of the 2012–13 CaMPR Phase I Planning Grants are:

Rachel J. Gordon, MD, MPH (PI), assistant professor of clinical medicine and clinical epidemiology,
“Staphylococcal skin and soft tissue infections in MSM: Risk factors and US-wide molecular epidemiology
with an internet-based randomized OTC intervention.”

Co–sponsored by the Department of Biomedical Informatics, this program provides an individual, with a one-year health practice research pilot award of $25,000 to apply operational interventions such as information technology, operations research, and simulation, to improve the practice of health care with the result of improved outcomes and efficiency. The recipient of the Irving Institute/DBMI health practice research pilot award is:

Katherine D. Crew, MD, MS, assistant professor of medicine and epidemiology, “Increasing Breast Cancer
Chemoprevention in the Primary Care Setting.”

(Gifts received November 27, 2012 – January 23, 2013)

A bequest of $582,000 was made toward a professorship in the Department of Medicine.

A foundation made a contribution of $300,000 to fulfill a $1,200,000 commitment to the Department of Medicine to
support gastrointestinal research in the Division of Digestive and Liver Diseases.

A donor made a gift of $275,000 to the Department of Medicine to support junior faculty in the Division of Cardiology.

A gift of $136,770 was made to the Department of Medicine to advance research in the Division of Geriatric Medicine and Aging.

A donor made a gift of $100,000 to the Department of Medicine to advance kidney disease research in the Division of Nephrology.

A donor made a gift of $100,000 to the Center for Translational Immunology in the Department of Medicine to advance research in type 1 diabetes.

2 Americans, 1 Swede share Crafoord science prize
January 17, 2013
Peter Gregersen of the Feinstein Institute for Medical Research near New York, Robert Winchester of Columbia University and Lars Klareskog of Stockholm's Karolinska institute were cited for discoveries related to rheumatoid arthritis. The academy said Thursday that the three scientists, who will share the award, "contributed to a basic understanding of how the most common and serious form of rheumatoid arthritis develops."

Rheumatoid Arthritis Discoveries Earn Prize for Three Scientists By Makiko Kitamura
January 17, 2013
Discoveries that may lead to prevention and better treatment of rheumatoid arthritis earned two Americans and a Swede the Crafoord Prize in Polyarthritis, awarded by the Royal Swedish Academy of Sciences. Peter K. Gregersen at the Feinstein Institute for Medical Research in Manhasset, New York; Robert J. Winchester at Columbia University; and Lars Klareskog of Stockholm’s Karolinska Institute will share the 4 million-kronor ($618,000) annual prize, the academy said in a statement today.


Tabas and Glass, 339 (6116): 166-172
January 11, 2013
Ira Tabas [of Columbia University’s Department of Medicine] reviews recent advances in anti-inflammatory therapies in treating and preventing chronic disease.  “Inflammation, once it gets going, can lead to tissue destruction. So the very elements of inflammation that can destroy the invading organisms can also destroy host tissue. And when tissue gets damaged, it can lead to tissue disfunction, according to Dr. Tabas.

Poor people participate in cancer trials less often  By Andrew M. Seaman
January 9, 2013
Poor people are less likely to take part in clinical trials for new cancer drugs… according to a new study. … “As a result of patients not participating in clinical trials, it takes a lot longer and it's much more expensive to develop new therapies," said Dr. Dawn Hershman, who worked on the study. "In this study we found one factor that contributes to that is patient income," Hershman, from Columbia University in New York, told Reuters Health.

Winter falls, bone fractures may point to osteoporosis  By Janice Lloyd
January 6, 2013
If you're unlucky enough this winter to slip on an icy surface and break a bone, you may need to do more than just treat the injury. … "People break bones, go to the emergency room, get the fracture fixed and are sent home,'' says Ethel Siris, director of the Toni Stabile Osteoporosis Center at Columbia University Medical Center in New York. "The fracture fixers are good at what they do, but their job is not to prevent the next fracture." That's up to you and your family physician, Siris adds.

DNA of Newtown Gunman Unlikely to Yield Clues of Violence — December 20, 2012
Connecticut investigators planning genetic studies of the body of Adam Lanza, who shot himself and 27 other people in the Dec. 14
school massacre, are unlikely to find clues about mental illness or violent behavior. While a number of genetic mutations have recently been linked to autism, Asperger’s syndrome and other related disorders, the vast majority of cases have no known cause, according to Wendy Chung, a clinical geneticist at Columbia University in New York. “Everyone is trying to play this back and figure out if there’s a way to avoid it in the future.”

For a Few, Kidney Defects May Be Linked with Mental Illness By Janice Wood
November 18, 2012
About 10 percent of kids born with kidney defects have alterations in their genomes known to be linked with neurodevelopmental delays and mental illness, according to a new study. … Researchers at Columbia University Medical Center predict that an evaluation for genomic alterations will eventually be part of the standard clinical workup. … “This changes the way we should handle these kids,” said kidney specialist Ali Gharavi, M.D., associate professor of medicine at Columbia University Medical Center, associate director of the Division of Nephrology, and an internist and nephrologist at New York-Presbyterian Hospital. … “If you talk to clinicians, they tell you that some of these kids behave differently,” said Dr. Simone Sanna-Cherchi, an associate research scientist in CUMC’s Department of Medicine.

Surprising genetic link between kidney defects and neurodevelopmental disorders in kids
November 15, 2012
About 10 percent of kids born with kidney defects have large alterations in their genomes known to be linked with neurodevelopmental delay and mental illness, a new study by Columbia University Medical Center (CUMC) researchers has shown. … "This changes the way we should handle these kids," said kidney specialist Ali Gharavi, MD, associate professor of medicine at CUMC, associate director of the Division of Nephrology, and an internist and nephrologist at NewYork-Presbyterian Hospital. The current study … was led by Dr. Gharavi and his colleague Simone Sanna-Cherchi, MD, an associate research scientist in CUMC's Department of Medicine.
[Picked up by SCIENCE NEWSLINE.]

Low Levels of Donor-Specific Antibodies Increase Risks for Transplant Recipients
November 15, 2012
Kidney transplant recipients who have even very low levels of preformed antibodies directed against a donated kidney have a significantly increased risk of organ rejection and kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). … Sumit Mohan, MD, Amudha Palanisamy, MD (Columbia University Medical Center) and their colleagues pored through the medical literature to find studies that looked at the health outcomes of kidney transplant recipients with such preformed donor-specific antibodies.

ABC6 WLNE-TV (Providence, RI)
Largest Prospective Study Shows IVUS-Guided Stent Placement Improves Patient Outcomes with Current Generation of Stents
November 14, 2012
Volcano Corporation (Nasdaq: VOLC), a leading developer and manufacturer of precision guided therapy tools designed to enhance the diagnosis and treatment of coronary and peripheral vascular disease, today announced that results from the largest study of its kind show that stent procedures guided by intravascular ultrasound (IVUS) resulted in better patient outcomes and fewer complications at 30 days and 12 months compared to procedures without IVUS, and were safe. … "The ADAPT-DES IVUS sub-study provides the strongest evidence to date that use of IVUS to guide optimizing placement improves patient outcomes," said Gregg W. Stone, M.D., FACC, FSCAI, Professor of Medicine at Columbia University College of Physicians and Surgeons and Director of Cardiovascular Research and Education at the Center for Interventional Vascular Therapy at New York-Presbyterian Hospital/Columbia University Medical Center.

What Can Healthcare Professionals Learn From Art? A Columbia University Physician Finds Answers At The Met
November 14, 2012
In an article published in the November 15 issue of The New England Journal of Medicine, Rita Charon, MD, PhD, professor of clinical medicine at Columbia University's College of Physicians & Surgeons (P&S) and executive director of the Program in Narrative Medicine at Columbia University, examines the ways in which both the physician and the artist inform their practice through recognition of the self in their work.

Ovarian Cancer Patients Have Lower Mortality Rates When Treated at High-Volume Hospitals

November 8, 2012
A study by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian/Columbia University Medical Center, recently e-published ahead of print by the Journal of Clinical Oncology, suggests that women who have surgery for ovarian cancer at high-volume hospitals have superior outcomes than similar patients at low-volume hospitals. … “It is widely documented that surgical volume has an important effect on outcomes following surgery,” said lead author Jason D. Wright, MD, the Levine Family Assistant Professor of Women's Health and the Florence Irving Assistant Professor of Obstetrics and Gynecology at CUMC, a gynecologic oncologist at NYP/Columbia, and a member of the HICCC. … “Our findings suggest that targeted initiatives to improve the care of patients with complications can improve outcomes,” said Dawn L. Hershman, MD, associate professor of medicine and epidemiology at CUMC, an oncologist at NYP/Columbia, co-leader of the Breast Cancer Program at the HICCC, and a co-author of the study.

Predicting the Cath Lab of the Future
By Dave Fornell
November 6, 2012
Hospitals constantly try to predict what the future holds when planning new facilities and equipment purchases that will need to last for the next decade. Martin Leon, M.D., director of the Center for Interventional Vascular Therapy, Columbia University Medical Center / New York-Presbyterian Hospital, attempted to answer that question for interventional cath lab technologies during Transcatheter Cardiovascular Therapeutics (TCT) 2012, making predictions through 2020. Leon is the founder and a director of TCT. … He said the biggest change will be in the types of procedures performed in the cath lab. New types of more complex procedures and devices, recently introduced or currently in trials, will increase cath lab volumes.

Chelation for Heart Disease: Study Shows Promise, but Experts Are Divided

By Alexandra Sifferlin
November 5, 2012
A government study raises more questions than answers about the validity of cleansing the body of heavy metals in order to prevent heart disease. … Even the study’s primary author, Dr. Gervasio A. Lamas, chief of the Columbia University Division of Cardiology at Mount Sinai Medical Center in Miami Beach, Florida said in an AHA statement that the medical community needs to “look carefully at these unexpected results.” He said a definitive answer will require further research, and the study authors need to understand whether “the signal is true, or whether it occurred by chance.”

NIH Trial Gives Surprising Boost To Chelation Therapy By Larry Husten
November 4, 2012
With a result that is likely to surprise and baffle much of the mainstream medical community, a large NIH-sponsored trial has turned up the first substantial evidence in support of chelation therapy for patients with coronary disease.  Known as TACT (Trial to Assess Chelation Therapy), the highly controversial trial was presented today at the AHA by  Gervasio Lamas .

Taming Stomachs With Fodmap Diet Spurs $8 Billion Market By Jason Gale
October 29, 2012
Sue Shepherd says she never expected to become famous for taming cantankerous stomachs. The 38-year-old Australian dietician invented a food regimen with a bizarre name in her early 20s to relieve symptoms of bloating and stomach cramps. It’s now being adopted internationally, changing the way doctors manage a set of digestive troubles known as irritable bowel syndrome. … There’s a “slow diffusion of knowledge” among physicians about food intolerance, said Peter Green, director of the Celiac Disease Center at Columbia University in New York.
Picked up from the San Francisco Chronicle.

St. Jude Device to Close Heart Holes Fails to Prevent Stroke By Michelle Fay Cortez
October 25, 2012
St. Jude Medical Inc. (STJ)’s device to plug openings in the heart after a stroke failed to definitively prevent repeat incidents in patients under age 60 compared with non-surgical drug treatment, two studies found.  … “I don’t think it will change practice a whole lot,” said Ajay Kirtane, director of the interventional cardiology fellowship program at Columbia University Medical Center/New York-Presbyterian Hospital in New York, said at the meeting. “I would like as a physician to have the option to discuss it with the patient and be able to use it if the patient elects to do so,” he said. “That would be the ideal scenario. To use it in everybody, I don’t think you can do that on the basis of this data.”

NY-Presbyterian Hospital announces participation in trial for hard-to-treat hypertension
October 25, 2012
Patients with hypertension whose blood pressure cannot be brought down to safe levels despite taking three or more medications may have some relief coming their way. An innovative, first-of-its-kind clinical trial for a device representing a dramatic shift in treatment approaches for the toughest-to-treat patients is currently being conducted at NewYork-Presbyterian Hospital. … "Hypertension is a serious health problem, and those with drug-resistant hypertension are at the greatest risk of developing organ damage, including heart attack, stroke and death," says Dr. Ajay J. Kirtane, an interventional cardiologist and chief academic officer of the Center for Interventional Vascular Therapy  at NewYork-Presbyterian/Columbia University Medical Center.

Life-Saving DNA Test Overlooked in Rise of Colon Cancer By Robert Langreth and John Lauerman
October 24, 2012
Genetic testing is becoming cheaper and more widespread, promising to usher in a revolution in cancer treatment. Yet, long-standing DNA tests are often overlooked for reasons including doctors’ ignorance and financial incentives discouraging companies from marketing them. Fifty years ago, Henry T. Lynch, then a medical resident in Nebraska, started tracking families with a high incidence of colon cancer and other tumors. While some were skeptical when he suggested the risks were inherited, geneticists proved him right in the mid-1990s by finding the genes that caused the condition. Lynch syndrome may account for about 3 percent of all colon cancer, or more than 4,000 cases a year in the U.S., said Heather Hampel, an Ohio State University genetic counselor. … “Lynch syndrome has been around for so many years, and we’re still not prepared to tackle it,” Fay Kastrinos, director of the hereditary gastrointestinal cancer program at Columbia University Medical Center in New York, said in a telephone interview.

Reported at TCT 2012: InspireMD MGuard Stent Meets Primary Endpoint of MASTER Trial, Significantly Improving Prospects of Heart Attack Survival
October 24, 2012
InspireMD, Inc. (OTC: NSPR) ("InspireMD" or the "Company"), announced its proprietary MGuard™ Embolic Protection Stent (EPS) was shown to be significantly superior when compared to standard bare metal and drug eluting stents in achieving complete ST resolution and restoring normal blood flow in a major study of 432 randomized patients undergoing emergency coronary intervention for potentially fatal heart attacks.  The data was reported at the Late Breaking Trials Session at the 24th Annual Transcatheter Cardiovascular Therapeutics (TCT) scientific meeting in Miami, FL today by Gregg W. Stone M.D., the study's chairman and the Director of the Cardiovascular Research and Education Center for Interventional Vascular Therapy at New York-Presbyterian Hospital/Columbia University Medical Center.

Mesh-covered Stent Helps Restoration of Blood Flow in Heart Attack Patients Undergoing PCI
October 24, 2012
A clinical trial found that the use of a next generation, micronet, mesh-covered stent demonstrated improved restoration of blood flow to heart tissue, compared to the use of either bare-metal or drug-eluting stents in heart attack patients undergoing angioplasty. …"Among heart attack patients undergoing primary percutaneous coronary intervention, the micronet, mesh-covered stent compared to conventional bare-metal and drug-eluting stents resulted in superior rates of epicardial coronary flow and complete ST-segment resolution," said study chairman, Gregg W. Stone, MD. Dr Stone is Professor of Medicine at Columbia University College of Physicians and Surgeons and Director of Cardiovascular Research and Education at the Center for Interventional Vascular Therapy at NewYork-Presbyterian Hospital/Columbia University Medical Center.
[Picked up by SCIENCE CODEX]

St. Jude Faces Boon-or-Bust Verdict on Heart-Plug Studies By Michelle Fay Cortez
October 24, 2012
For two decades, doctors have used a dime-sized plug made by St. Jude Medical Inc. to close holes found in the hearts of stroke victims in a surgery that’s based largely on a medical theory. … New data from two studies testing whether the surgery stops repeat strokes could either cripple sales for the device made by St. Paul, Minnesota-based St. Jude, or send revenue surging. … With positive data “everyone in the world will be looking for patients” to do the surgery in, said Gregg Stone, director of cardiovascular research at New York-Presbyterian Hospital/Columbia University Medical Center for Interventional Vascular Therapy. Negative results “will truly challenge” using the procedure “in any patient.”

Why leaving the heating off and avoiding the gym could help you lose weight By Peta Bee
October 22, 2012
Unlike the more familiar, yellowish-white body fat you pile on if you eat too many calories, brown fat — apparently the colour of chocolate — does the opposite, burning excess energy to generate heat and maintain the body’s core temperature. … In one study, published in the journal Cell in August, researchers at Columbia University medical school managed to ‘brown’ white fat with the use of a class of drugs called thiazolidinediones (TZDs), sometimes used to lower blood sugar in type 2 diabetes. ‘Turning white fat into brown fat is an appealing therapeutic approach to staunching the obesity epidemic,’ says lead researcher Professor Domenico Accili. ‘But so far it has been difficult to do so in a safe and effective way.’

Green tea extract may prevent breast cancer: Study
October 19, 2012
Green tea has long been known for its medicinal benefits and now researchers have found that it also contains an extract which can inhibit mechanisms that promote tumour cell growth in breast cancer. Researchers from the Columbia University Medical Center in New York found that the extract Polyphenon E, appears to inhibit vascular endothelial growth factor and hepatocyte growth factor, both of which promote tumour cell growth, migration and invasion. … "Many preclinical studies have looked at epigallocatechin-3-gallate, or EGCG, which is one of the main components of green tea, and the various possible mechanisms of its action against cancer, but it is very difficult to do those same kinds of studies in humans," researcher Katherine D Crew, said.

New York Times News Service
High stress could be damning By Amanda Shaffer
October 10, 2012
For years, researchers have investigated how the body loses the ability to produce enough insulin, a hallmark of diabetes. … [T] the body can become resistant to insulin, and the beta cells of the pancreas, which produce the hormone, must work harder to compensate. Eventually, the thinking goes, they lose the ability to keep up. … In mice with Type 2 diabetes, the researchers showed that beta cells that had lost function were not dead at all. Most remained alive, but in a changed form. They reverted to an earlier developmental, “progenitor,” state. It’s as if these cells are “stepping back in time to a point where they look like they might have looked during their development,” said Dr. Domenico Accili, director of the Columbia University Diabetes and Endocrinology Research Center, who led the new work. … In the new work, published in September in the journal Cell, Dr. Accili, Chutima Talchai, then a postdoctoral fellow in his laboratory, and their colleagues genetically engineered mice that lacked FOXO1 in beta cells.

Picked up by MSNBC News
Women who have heart attacks more likely to call 911 By Amy Norton
October 9, 2012
Women suffering symptoms of a heart attack are more likely than their male counterparts to dial 911 - but there's a lot of room for improvement for men and women, alike, a new study finds.  … "I think you should have a low threshold for calling," lead researcher Dr. Jonathan D. Newman of Columbia University Medical Center in New York told Reuters Health. "Rather than ‘watching and waiting.'"  In the new study, Newman and his colleagues looked at how often New Yorkers with heart symptoms called 911. They found that among 184 heart attack sufferers, women were more likely than men to call: 57 percent did, versus 28 percent.

Tomatoes Linked to Lower Stroke Risk By Julielynn Wong
October 8, 2012
Tomatoes are linked to a decreased risk of stroke in men, a new study finds. … his study further supports the importance of consuming fruits and vegetables rather than nutritional supplements in the prevention of conditions like stroke and heart disease, said Dr. Lori Mosca, professor of medicine at Columbia University Medical Center and director of preventive cardiology at New York-Presbyterian Hospital in New York City, who was not involved in the study.

NYC bans big, sugary drinks at restaurants By David B. Caruso
September 15, 2012
Over a decade, New York City has outlawed smoking in bars and offices, banned trans fats, and forced fast-food restaurants to list calorie counts on their menus. Now, the Big Apple has set its sights on sugary beverages with a first-in-the-nation rule barring restaurants, cafeterias and concessions stands from selling soda and other calorie-rich drinks in containers larger than 16 ounces. … "We are dealing with a crisis ... we need to act on this," said Board of Health member Deepthiman Gowda, a professor of medicine at Columbia University.
[Also covered by REUTERS]

Health Panel Approves Restriction on Sale of Large Sugary Drinks By Michael M. Grynbaum
September 14, 2012
Seeking to reduce runaway obesity rates, the New York City Board of Health on Thursday approved a ban on the sale of large sodas and other sugary drinks at restaurants, street carts and movie theaters, the first restriction of its kind in the country. … Dr. Deepthiman K. Gowda, a professor of medicine at Columbia University and a member of the Board of Health, said he recognized that the public had concerns about the plan.

Why type 2 diabetes is a bit like The Bourne Identity
September 14, 2012
In The Bourne Identity, the eponymous hero is presumed dead by his former employers, but turns out to have merely lost his memory. Thus unburdened, he attempts to change his fate. Which reminds me of diabetes. People with type 2 diabetes face two problems, both related to insulin – the hormone that regulates the levels of sugar in our blood. They don’t respond properly to it (they become insulin resistant), and they don’t make enough of it… The typical explanation is that the beta-cells – a type of insulin-making cells within the pancreas – die off. But Domenico Accili from Columbia University has a different idea. By studying diabetic mice, he has found beta-cells do indeed disappear over time, but not because they die. Instead, they revert back to a more basic type of cell that doesn’t produce insulin.

Beta Cells Turn Younger, Not Older, During Type II Diabetes By Anette Breindl
September 14, 2012
In findings that, in the opinion of senior author Domenico Accili, turn the current approach to treating Type II diabetes on its head, researchers at Columbia University have discovered that in Type II diabetes, the insulin-producing pancreatic beta cells whose failure is at the core of the disease do not die. Quite the opposite: They become more stem cell-like. That's the conclusion that Accili, who is at Columbia University, and his colleagues reached after performing lineage tracing studies on pancreatic beta cells in mouse models of Type II diabetes… In fact, the findings, which appeared in the Sept. 13, 2012, issue of Cell, are pretty much the opposite of what the team expected when they started their tracing studies.

Transformer Cells in Diabetes By Ed Yong
September 13, 2012
As cases of type 2 diabetes progress, people get increasingly worse at making their own insulin, a hormone that controls levels of sugar in the blood. The usual explanation is that the insulin-producing beta cells of the pancreas are dying. But according to a study published today (September 13) in Cell, the beta cells of several breeds of diabetic mice don’t die at all. Instead, they de-differentiate into a less specialized cell type. If a similar mechanism is occurring in humans, it might be possible to ease the progression of diabetes by finding new ways of preventing dedifferentiation, the authors suggest. “This piece of work is not only thorough and methodologically superb but highly original and relevant,” said Ele Ferrannini, a diabetes biologist from the CNR (National Research Council) in Pisa, Italy… For Domenico Accili of Columbia University in New York, the prevailing idea about dying beta cells never quite fit all the available data.

Study explains decrease in insulin-producing beta cells in diabetes

September 13, 2012
Scientists generally think that reduced insulin production by the pancreas, a hallmark of type 2 diabetes, is due to the death of the organ’s beta cells. However, a new study by Columbia University Medical Center (CUMC) researchers shows that beta cells do not die but instead revert to a more fundamental, undifferentiated cell type. … “The prevailing theory is that the death of beta cells is responsible for the decline in insulin production in type 2 diabetes,” said study leader Domenico Accili, MD, professor of Medicine and the Russell Berrie Foundation Professor at CUMC. “But when you look at a diabetic pancreas, you find very few, if any, dead beta cells. So, the organ dysfunction is out of proportion with the number of dead cells. Nobody has had a plausible explanation for this.” Dr. Accili and co-author Chutima Talchai, PhD, suspected that some answers might lie in the activity of FoxO1 protein. FoxO1 - a transcription factor, or protein that controls when genes are switched on or off - serves as a kind of gauge of the body’s nutritional status.

Fumbled DNA Tests Mean Peril for Breast-Cancer Patients By Robert Langreth
September 10, 2012
More than 2,700 diseases can now be identified through gene testing, compared with fewer than 800 in 2000, according to the government-funded website GeneTests. … About 74 percent of internists said their knowledge of genetics was somewhat or very poor and 79 percent wanted more training on when to order the tests, according to a Columbia University study surveying 220 internists.  “Even if you have been out of medical school for five years, you are totally out of date,” said Wendy Chung, a pediatrician and geneticist at Columbia University Medical Center who was a co-author on the study.

Ira Goldberg, MD, Medicine, has received $1.76 million until 2016, in a competitive renewal, from
the National Heart, Lung, and Blood Institute for “Mechanisms of Fatty Acid Uptake By Cardiac

Shonni J. Silverberg, MD, Medicine, has received $269,000 over four years from the University of
Miami and the National Heart, Lung, and Blood Institute for “FGF23 and the Risk of Stroke and
Cognitive Decline.”

Siddhartha Mukherjee, MD, DPhil, Medicine, has been invited to speak before the Congressional
Biomedical Research Caucus on Sept. 12, 2012, in Washington, D.C.

Another foundation made a gift of $450,000 toward a $2.25 million commitment to the Division of Endocrinology to advance research in osteoporosis and other bone diseases.

A contribution of $200,000 was made to advance research and clinical care in the Departments of Surgery and Medicine.

More Strokes After Bypass Than Stent Procedures – August 22, 2012
People undergoing bypass surgery to improve blood flow to the heart are more likely to suffer a stroke afterward than those who have a stent inserted instead, according to a new look at past evidence. “There are some patients with coronary artery disease where clearly angioplasty (inserting a stent) is the best, least invasive way to go,” said Dr. Gregg Stone from Columbia University Medical Center in New York, who worked on the study.

Study: Acute Coronary Events Linked With PTSD By Rebecca Voelker
July 11, 2012
… PTSD is most commonly perceived as resulting from exposure to such disturbing events as military combat, sexual assault, and man-made or natural disasters. Common symptoms include intrusive thoughts, nightmares, elevated heart rate and blood pressure, and avoiding reminders of the triggering event. “It is also quite common among patients who have had a severe coronary event,” said lead author Donald Edmondson, PhD, of the Columbia University Medical Center in New York, NY, in a statement.

ABC launches a medical documentary; magazine offers heat-specific training tips By Maggie Fazeli Fard
July 9, 2012
The eight-episode series, a follow-up to “Boston Med” and “Hopkins,” focuses on doctors, nurses, employees and patients at two of the hospital’s units, the Columbia University and Weill Cornell medical centers. Heart surgeon Mehmet Oz is among the doctors featured on the show, but producers say the series is more than a behind-the-scenes look at the life of a famous talk-show host.
[Also covered by NEWSDAY 'NY Med' with Dr. Oz: Beautiful and moving;  LOS ANGELES TIMES Review: ABC's 'NY Med' brings medicine to life; VANCOUVER SUN ABC's Wrong returns with NY Med; KANSAS CITY STAR The doctor will see you now on 'NY Med'.]

ABC documentary series 'NY Med' follows dramatic events at a New York hospital
By David Hinckley
July 8, 2012
It’s mid-April 2011, and producer Terence Wrong and his team are ensconced in an office on the 12th floor at New York-Presbyterian Hospital/Columbia University Medical Center. Camera operators dressed in green hospital scrubs get their gear and head out for various corners of the hospital, where they will spend hours looking over the shoulders of doctors, nurses and patients to get the raw material for what will become ABC News’ “NY Med,” an eight-part series set to launch Tuesday at 10 p.m. … One of the elements that sets “NY Med” apart from Wrong’s earlier medical shows is the presence of a face TV viewers will recognize: Dr. Mehmet Oz, one of the two or three most prominent “TV doctors” in the country thanks to his long stint with Oprah and now his own show.

Celiac Disease Under-Diagnosis Could Be Attributed To Low Biopsy Rates: Study
July 4, 2012
Celiac disease -- the condition that triggers an immune response to foods containing gluten -- has a reputation for being under-diagnosed in the United States. But why? Columbia University Medical Center researchers may have a reason. … "This study shows that some of these undiagnosed patients may be coming to see a gastroenterologist and still are not getting the biopsy they need for a diagnosis," said study researcher Dr. Benjamin Lebwohl, M.D., M.S., in a statement. Lebwohl is an assistant professor of clinical medicine in the Division of Digestive and Liver Diseases and a gastroenterologist and epidemiologist at the Celiac Disease Center at Columbia.

Staving Off Repeat Fractures With Bone Tests, Counseling By Melinda Beck
July 3, 2012
It’s bad enough that osteoporosis causes two million broken bones in the U.S. each year, as WSJ’s Health Column reports. But many of those are repeat fractures that could have been prevented if older people had been counseled about osteoporosis after their first bone break, experts say. … “Orthopedic surgeons do a really good job of fixing broken bones, but they don’t take time to go through the whole calcium discussion or talk about medications that could stop bone loss,” says Dr. Ethel Siris, director of the Toni Stabile Osteoporosis Center at Columbia University and a member of the NBHA’s executive board.

Dutifully Taking Your Calcium Pill? It May Be Too Much By Melinda Beck
July 2, 2012
While many people aren't getting enough calcium, new research cautions that some people may have the opposite problem: They could be getting too much. … "It's gotten very confusing but it doesn't need to be," says Ethel Siris, director of the Toni Stabile Osteoporosis Center at Columbia University Medical Center in New York.

Prenatal Exposure to Common Household Chemical Linked to Eczema
June 28, 2012
Babies born to women who were exposed to the common household chemical butyl benzyl phthalate (BBzP) during pregnancy are at greater risk for childhood eczema, new research suggests. BBzP is used in vinyl flooring, artificial leather and other materials, and can be released into the air, the researchers said… "We know allergies are a factor with some childhood eczema, but our data suggests that is not the case when BBzP is involved," senior study author Dr. Rachel Miller, an associate professor of medicine and environmental health sciences at New York-Presbyterian Hospital/Columbia University Medical Center, said in the news release. "However, these are important findings, given that eczema is a common and uncomfortable disease of early childhood."

Alex Trebek Recovers From Mild Heart Attack
June 25, 2012
…There is also news about the role of stress for those recovering from heart disease. Gary Dorman says his heart attack has robbed him of everything he loved – doctors diagnosed him with PTSD. Dr. Donald Edmondson of Columbia University Medical Center, “Just like in war, heart attack is an individual who is experiencing a life-threatening event.”

Brain Banks for Autism Face Dearth By Benedict Carey
June 25, 2012
Clare True’s was one of 150 specimens stored in a Harvard brain bank that was ruined because of a freezer failure, doctors acknowledged this month. The loss, while a setback for scientists studying disorders like Huntington’s disease, Alzheimer’s and schizophrenia, especially mortified those working on autism, for it exposed what is emerging as the largest obstacle to progress: the shortage of high-quality autopsied brains from young people with a well-documented medical history. The malfunction reduced by a third Harvard’s frozen autism collection, the world’s largest… “There’s just no question that human tissue is the gold standard for research, said Dr. Gerald D. Fischbach, a professor emeritus at Columbia and director of life sciences at the Simons Foundation, which promotes autism research.

Q&A with Wafaa El-Sadr: Leading HIV expert on the global epidemic and its bearing in Egypt By Steven Viney
June 23, 2012
Egyptian-born Wafaa El-Sadr — originally a graduate from Qasr al-Aini Medical School in 1975 — is currently the director of the International Center for AIDS Care and Treatment Programs (ICAP), and the director of the Center for Infectious Disease Epidemiologic Research at Columbia University. She has been at the forefront of the battle against HIV since reports of the epidemic first surfaced in the 1980s. In 2009, Scientific American listed her as one of ten visionaries ‘Guiding Science for Humanity,’ and the Utne Reader listed her as one of fifty ‘Visionaries Who Are Changing Your World.’ This week, El-Sadr was back in her hometown of Cairo to receive an honorary doctor of science degree from the American University in Cairo. Egypt Independent took the opportunity to speak with her about her current views on the HIV epidemic, both globally and in Egypt.

Effects of High Blood Pressure Drug May Mimic Celiac Disease
June 22, 2012
A new report suggests that the common blood pressure drug olmesartan (Benicar) can cause symptoms that mimic celiac disease, leading to misdiagnosis and unnecessary treatment. It's not clear how often people who take the blood pressure-lowering drug will develop the gastrointestinal problems that are similar to those caused by celiac disease. For the moment, though, the side effects appear to be unusual, said Dr. Peter Green, director of the Celiac Disease Center at Columbia University Medical School [sic], who was not involved with the study. Still, Green noted, his center has seen patients who developed celiac disease-like symptoms while taking olmesartan and some have been quite ill. "One went into kidney failure and needed dialysis," he said.

When A Health Crisis Leads to PTSD
By Sushma Subramanian
‎June 22, 2012‎
…One in 8 heart attack survivors develop PTSD, according to study from Columbia University Medical Center, published online in the journal PLoS One… Patients in their 50s or younger — under the typical age for heart attack sufferers — are more likely to experience PTSD after a heart event. Donald Edmondson, assistant professor of behavioral medicine at Columbia University and a researcher of the PLoS ONE study, adds that people who feel more in danger during a medical trauma, or who feel they have less control of their health, also are more likely to experience the disorder.

[Also covered by: YAHOO! PTSD and Heart Patients: More Common Than Once Thought; MEDICAL NEWS TODAY: PTSD Caused By Heart Attack Raises Recurrence And Mortality; ISCIENCETIMES.COM: Heart Attack Patients Often Develop PTSD; PSYCHCENTRAL: For Some, Heart Attack May Lead to PTSD; NEWSER: Heart Attack Side Effect: PTSD]

How Storytelling is Changing The Way Doctors Treat Illness By Abigail Rasminsky
June 1012
In the early '80S, a few years into her career treating patients in a cramped clinic in New York City's Washington Heights, Rita Charon felt overtaxed. Every case was a puzzle, and more often than not, at least one of the pieces didn't seem to fit. But the Harvard-educated internist, now 62, says her problem wasn't a lack of scientific knowledge: "I wasn't a good enough listener." … Charon is the founding director of the Program in Narrative Medicine at Columbia University, where future MDs participate in writing workshops and examine texts by authors like Camus, Tolstoy, and Walt Whitman (who was a nurse during the Civil War). The idea is that these literary exercises will enhance the students' ability to interpret stories—and to take the imaginative leap into a world other than their own. "When doctors can see illness from their patients' eyes," says Ronald Drusin, MD, vice dean for education at Columbia's College of Physicians and Surgeons, "they become better doctors." … Sayantani Dasgupta, MD, who teaches narrative medicine at Columbia University, says the key to sharing your health history is thinking of it as a story…

Obesity epidemic stems from environment, panel says
May 8, 2012
The Institute of Medicine is recommending that schools and workplaces encourage people of all ages to exercise more, and suggested industry-wide guidelines on marketing food to children. NBC’s Robert Bazell reports... Dr. Robin Goland of Columbia University Medical Center, states, “Our pediatricians are seeing obese two-year-olds and four-year-olds. We have five-year-olds with impaired glucose tolerance. We have eight-year-olds with type 2 diabetes. This is a catastrophe.”

Aspirin Seen to Be as Effective as Warfarin By Nicholas Bakalar
May 7, 2012
People with congestive heart failure are often treated with warfarin to prevent blood clots, but a large randomized double-blinded trial has found that aspirin works just as well. … “The advantage is that aspirin is easier to take,” said Dr. Shunichi Homma, the lead author and a professor of medicine at Columbia University.

Aspirin works as well as blood thinners warfarin, or Coumadin, in heart patients
May 7, 2012
Aspirin works as well as the blood thinner warfarin, or Coumadin, in most patients with heart failure when it comes to preventing death, stroke or brain hemorrhage, said a major international study on Wednesday. The findings published in the New England Journal of Medicine came from a landmark clinical trial that lasted 10 years and tracked 2,305 patients in 11 countries... "Since the overall risks and benefits are similar for aspirin and warfarin, the patient and his or her doctor are free to choose the treatment that best meets their particular medical needs," said lead investigator Shunichi Homma of Columbia University Medical Center.

ABC World News Tonight
Domino's to Make Gluten-Free Pizza
May 7, 2012
Pizza chain will offer option for customers who avoid wheat.  … Dr. Peter H.R. Green, director of Columbia University’s Celiac Disease Center, warns, “A gluten-free diet is not entirely healthy; often it lacks fiber. And the manufacturers of wheat flour fortify wheat flour with vitamins and minerals... It’s been demonstrated that if you’re on a gluten-free diet long-term, you can actually become B- vitamin deficient.”

Yong-Guang Yang, MD, PhD, Department of Medicine-Immunology, has received $1.84 million
over five years from the National Institute of Allergy and Infectious Diseases for “Role of CD47 in
Xenograft Rejection by Macrophages.”

Henry Ginsberg, MD, Department of Medicine-Preventive Medicine, has received $1.6 million
over three years from the National Heart, Lung, and Blood Institute for “Pathways of Fenofibrate
Effects on Cardiovascular Outcomes in ACCORD.”

Nir Uriel, MD, Department of Medicine-Cardiology, has received $696,000 over five years from
the National Heart, Lung, and Blood Institute for “Insulin Resistance in Chronic Heart Failure:
Pathophysiology and Potential for Reversal.”

Milan Stojanovic, PhD, Department of Medicine-Nephrology, has received $474,000 over two
years from the National Institute of Biomedical Imaging and Bioengineering for “Isolation of
Narrow Subpopulations of Cells using Molecular Computing Cascades.”

Mathew Maurer, MD, Herbert Irving Comprehensive Cancer Center, received $450,000 over
three years from the Komen (Susan G.) Breast Cancer Foundation for “A Novel Combination
Therapy for Triple Negative Breast Cancer: Erlotinib And Metformin.” He also has received
$250,000 over one year from the Hope Foundation for “CSI-Lethality: A Novel Strategy for
Cancer Therapeutic Target Discovery.”

Jennifer Amengual, MD, as assistant professor, Department of Medicine-Oncology.
Suzanne Lentzsch, MD, PhD, as assistant professor, Department of Medicine-Oncology.
Markus Mapara, MD, as assistant professor, Department of Medicine-Oncology.

Can Running Make Us Happier?
By Ilena Silverman
April 19, 2012
Siddhartha Mukherjee … tells us about researchers at Columbia University who discovered that feeding mice Prozac made them less anxious and more adventurous — but only when there was simultaneous brain-cell growth in the hippocampus.

One-third of U.S. not getting colon screen

April 14, 2012
The No. 2 U.S. cancer killer -- colon cancer -- is often preventable and highly curable if caught early, U.S. researchers said. … However, despite the availability of effective screening tests, about one-third of U.S. adults are not getting screened for colorectal cancer, said Dr. Benjamin Lebwohl, a gastroenterologist at NewYork-Presbyterian/Columbia University Medical Center.

Mouse Study Hints at New Path for Diabetes Treatment By Serena Gordon
April 12, 2012
A potential new treatment for type 2 diabetes targets the hormone glucagon instead of insulin, according to a new study in mice… What's more, the researchers didn't see any adverse effects from the treatment… "A new target for the adverse effects of glucagon on diabetes has been identified, and with treatment we got rid of all the bad stuff, but didn't cause side effects," said the study's lead author, Dr. Ira Tabas, a distinguished professor of medicine at Columbia University Medical Center, in New York City.
Also covered by: Imperfect Parent New study reveals non-insulin diabetes treatment and  Targeting Glucagon Pathway May Offer a New Approach to Treating Diabetes].

Should You Go Gluten-Free?
By Katie Moisse
April 10, 2012
Miley Cyrus is the latest celeb to go gluten-free, a move some experts are calling the low-carb diet of the decade… one in 100 Americans suffers from a severe gluten allergy called celiac disease, and many more have gluten sensitivities that leave them feeling tired, achy and bloated. …  “Many people with celiac disease would get the label of irritable bowel syndrome,” said Dr. Peter Green, director of Columbia University’s Celiac Disease Center in New York.

Immune Mouse that Fully Recapitulates Individual Human Immune System Developed
March 15, 2012
Scientists report on the development of a mouse model that recapitulates the immune system of a single adult human. In contrast with existing humanized mouse models with immune systems derived from transplanted fetal and Columbia University Medical Center team is derived from a relatively few adult human HSCs. These could effectively be taken from any human volunteer or patient. Megan Sykes, M.D., and colleagues, say the the resulting "personalized immune" (PI) mice generated a robust and diverse repertoire of fully functional T cells that were self-tolerant, and exhibited immune responses that mimicked those of the adult CD34+ cell donor.

Partners in Research’ presents new collaboration for Columbia and community By Sandra E. Garcia
March 14, 2012
Columbia University, with its extensive resources for experimental, social and field research, among many such rigorous pursuits, has often turned to local organizations in northern Manhattan to conduct its studies. … The research study also included findings from the Washington Heights-Inwood Council on Aging (WHICOA) and the Columbia University Irving Institute for Clinical and Translational Research. … Romero worked alongside Dr. Joyce Moon-Howard, Academic Principal Investigator of the Partners in Research Program and Mailman School Assistant Professor of Clinical Social Medical Sciences. … Dr. Rafael Lantigua, Professor of Clinical Medicine and Associate Director of the Division of General Medicine, has decades of experience in the medical field and a long history of community activism in Washington Heights. .. Sandra Harris, Assistant Vice President for Government and Community Affairs for Columbia University was enthused also about the collaboration, and spoke to the University's commitment to its success.

Gut Cells Turned To Insulin Factories - New Type l Diabetes Treatment
March 13, 2012
According to a study conducted in mice by researchers at Columbia University Medical Center and published 11 March 2012, in the journal Nature Genetics, cells in the intestine of patients with type 1 diabetes could be lured into generating insulin, eliminating the need for a stem cell transplant. … The study was carried out by Chutima Talchai, Ph.D, a New York Stem Cell Foundation-Druckenmiller Fellow, and Domenico Accili, M.D., professor of medicine at Columbia University Medical Center.

Why women may not even know they're having a heart attack By Felicia Stoler
February 10, 2012
In 1990, Dr. Marianne Legato, founder of the Partnership for Gender-Specific Medicine at Columbia University, was asked by the American Heart Association (AHA) to review the literature about women and coronary disease.  Over the last two decades, we have learned that heart disease is different in women than in men.

Radioisotope Recipe Lacks One Ingredient: Cash
By Matthew L. Wald
February 7, 2012
For years, scientists and policy makers have been trying to address two improbably linked problems that hinge on a single radioactive isotope: how to reduce the risk of nuclear weapons proliferation, and how to assure supplies of a material used in thousands of heart, kidney and breast procedures a year. … The isotope is technetium 99m, or tech 99 for short. … Dr. Andrew J. Einstein, an assistant professor of clinical medicine at the Columbia University College of Physicians and Surgeons, who testified before a Senate committee in 2008 about the isotope shortage, said supplies were adequate at the moment.

New Guide to Who Really Shouldn't Eat Gluten

February 7, 2012
[A] group of 15 experts from seven countries is proposing a new classification system for the gluten-related disorders plaguing a growing number of people around the world for unknown reasons. … "Many physicians would roll their eyes and say, 'God, another crazy person with food sensitivities,' " says Peter Green, director of the Celiac Disease Center at Columbia University and a co-author of the proposal. "It's only now that studies are coming out showing that there's something real about gluten sensitivity."

Komen and Planned Parenthood: The pink army revolts
By Kate Dailey
February 3, 2012
"I've given a lot of talks on breast cancer. At the end of the session people will come up to me and say, 'I have lung cancer. Why doesn't anyone ever give a talk about that?'" says Barron Lerner, author of The Breast Cancer Wars and professor of medicine at the Columbia University Medical school.

Too many rheumatoid arthritis patients inactive, study finds By Steven Reinberg
January 27, 2012
More than 40 percent of rheumatoid arthritis patients live a sedentary life, a new study finds. … Dr. Jon Giles, an assistant professor of medicine in the division of rheumatology at Columbia University's College of Physicians and Surgeons in New York City, said that "the most striking aspect to me about the paper is that although we generally consider joint pain and damage as the reason that rheumatoid arthritis patients may not exercise, this does not appear to be the primary driver of lack of exercise in the group studied.”

Joan Bathon, MD, Department of Medicine-Rheumatology, has received $2.9 million over five years from the National Institute of Arthritis and Musculoskeletal and Skin Diseases for “Inflammation and Cardiovascular Disease in RA.”

Robin Goland, MD, Department of Medicine-Endocrinology and the Naomi Berrie Diabetes Center, and Raphael Clynes, MD, PhD, Department of Pathology and Cell Biology, have received $1.9 million over five years from the NIH and University of Pittsburgh for “Nutritional Primary Prevention of Type 1 Diabetes.”

Siddhartha Mukherjee, MD, Department of Medicine-Oncology, has received the Guardian First Book award for his nonfiction book, The Emperor of All Maladies.

A bequest of $1.456 million will fulfill a pledge to establish a professorship in the Department of Medicine.

A bequest of $208,450 will support cardiovascular research in the Department of Medicine.

The Breast Cancer Research Foundation made a payment of $112,499 toward a commitment of $224,999 to support studies in cancer survivorship in the Department of Medicine.

U.S. Behind The Curve In Drunk Driving, Author Finds
November 17, 2011
When Barron Lerner was writing his book on the history of drunk driving in America — and efforts to control it — he carried out an experiment at home that involved a bottle of vodka, a shot glass and a Breathalyzer. He was the guinea pig. "I was trying to figure out just how drunk you had to be in order to not drive safely," says Lerner, a professor of medicine and public health at Columbia University, who wrote One for the Road. He decided to drink and test his levels — but he didn't actually get into a car.

When Lobotomy Was Seen as Advanced
– December 20, 2011
Most of us recall lobotomies as they were depicted in the movie “One Flew over the Cuckoo’s Nest”— horrifying operations inappropriately used to control mentally ill patients. But in the 1950s, surgeons also used them to treat severe pain from cancer and other diseases. Now a Yale researcher has uncovered surprising new evidence of a famous patient who apparently received a lobotomy for cancer pain during that time: Eva Perón, the first lady of Argentina, who was known as Evita. Article authored by Dr. Barron H. Lerner, professor of medicine and public health at Columbia University Medical Center, whose book, “One for the Road: Drunk Driving Since 1900,” was recently published.

Few Women Get Breast Reconstruction After Mastectomy – December 8, 2011

Few women undergo breast reconstruction after a mastectomy, despite the known cosmetic and psychological advantages, a new study indicates. “The immediate reconstruction rates are higher in women with DCIS (ductal carcinoma in situ, an early stage cancer) than with invasive cancer,” said Dr. Dawn Hershman, an associate professor of medicine and epidemiology at Columbia University Medical Center, in New York City.

A Reminder on Maintaining Bone Health
By Jane E. Brody
November 1, 2011
… Most of the news about osteoporosis concerns the side effects of current therapies and preventives. But it is important to put these effects in perspective — and to focus on treatment benefits and practical measures that can help to prevent costly and debilitating fractures in fragile bones. … “Age is itself a major risk factor for fracture,” said Dr. Ethel Siris, director of the osteoporosis clinic at Columbia University Medical Center in New York.

Obama’s Cholesterol Should Be Lower, Doctors Say By Carrie Gann
November 1, 2011
When it comes to President Obama’s health, some cardiologists recommend that his cholesterol levels go the way of his approval ratings: low. … Although his new numbers are an improvement, Dr. Lori Mosca, director of preventive cardiology at Columbia University Medical Center in New York, said the president’s score could be lower.

Heart-Device Makers May Find Shrinking-Stent Flaw Hurts $4 Billion Market

By Michelle Fay Cortez
November 1, 2011
A complication that causes drug- coated heart stents to weaken and shrink will be reviewed at a medical meeting next week, researchers said. The stent flaw, known as longitudinal compression, was added to the agenda at the Transcatheter Cardiovascular Therapeutics meeting that starts next week in San Francisco, said Gregg Stone, director of cardiovascular research at New York Presbyterian Hospital/Columbia University Medical Center and director of TCT.

Painting the Town Pink to Raise Millions By Marshall Heyman
October 18, 2011
The ninth annual Avon Walk for Breast Cancer, which took place this weekend in New York, was big business. … Sitting with two of the day's beneficiaries—Ms. Miller from CancerCare and Dawn Hershman, a professor of medicine at New York-Presbyterian Hospital/Columbia University Medical Center—Ms. Kurzig was wearing a magenta leather jacket and a pink ribbon necklace.

Friends Still Let Friends Drive Drunk By Barron H. Lerner, M.D..
October 18, 2011
Drunken driving remains among the most preventable of violent injuries. … Barron H. Lerner, M.D., Ph.D., professor of medicine and public health at Columbia University Medical Center, is author of “One for the Road: Drunk Driving Since 1900,” just published by the Johns Hopkins University Press.


The Shortfalls of Early Cancer Detection By Barron H. Lerner, MD

October 11, 2011
The outcry among many physicians and patients over a government panel’s recent announcement that healthy men should no longer receive P.S.A. blood testing to detect prostate cancer is rooted in a long and impassioned history among cancer screening advocates that early detection must always save lives. But as science has taught us, that’s not always the case. … Dr. Barron H. Lerner, professor of medicine and public health at Columbia University Medical Center, is the author of “The Breast Cancer Wars” and, this month, “One for the Road: Drunk Driving Since 1900.”

Coffee Grinds Down Risk Of Depression In Women, Study Finds
By Kafi Drexel
September 27, 2011
Perhaps beating any drink special for ladies, a new study suggests that coffee fix might give women more than a temporary boost. Women who drank four cups or more a day over a long period of time had a 20 percent lower risk of depression. "There may be something in coffee that makes the body feel better or give you an endorphin or what they call neurotransmitter that's improved in the body," said New York Presbyterian Columbia Internist Dr. Seth Feltheimer.

FDA to review safety of osteoporosis drugs
By Steven Reinberg
September 13, 2011
U.S. Food and Drug Administration advisers recommended Friday that osteoporosis drugs such as Fosamax, Actonel, Boniva and Reclast come with revised labels, clarifying how long a patient should take a drug before potential health risks set in….While these side effects shouldn't be downplayed, "when you consider the number of very dangerous, life-threatening fractures that are prevented by these drugs, the benefits dwarf the side effects," said Dr. Elizabeth Shane, also a professor of medicine at Columbia University in New York City.

Celiac disease and Pregnancy
September 8, 2011
An illness that's becoming better understood is celiac disease, and one effect is infertility. Interview with Dr. Peter Green.

WALL STREET JOURNAL (log-in required)
FDA Panel to Weigh Osteoporosis Drug Risks By Jennifer  Corbett Dooren
September 6, 2011
A widely prescribed class of drugs for osteoporosis has been shown to prevent common hip and spine fractures associated with the bone-destroying disease, but there are concerns that the drugs might cause a different set of problems….Elizabeth Shane, who was co-chairwoman of the American Society for Bone and Mineral Research's task force that looked at atypical thigh fractures last year and is a professor of medicine at Columbia University, says the risk of an atypical thigh fracture is very low and doctors need to balance the need to protect patients with osteoporosis against common, often debilitating hip and other fractures.

F.D.A. to Review Safety of Popular Bone Drugs By Duff Wilson
September 5, 2011
Two advisory panels of the Food and Drug Administration will consider on Friday whether to recommend requiring women who use popular bone drugs like Fosamax to take “drug holidays” because of rising concerns about rare side effects with long-term use, according to people involved in the review….“The risk-to-benefit ratio strongly favors biphosphonate therapy,” said Dr. Elizabeth J. Shane, a Columbia University professor and bone specialist who was co-chairwoman of task forces on the femur and jaw issues for the American Society for Bone and Mineral Research. “And while we are upset and worried and do not want to do anything that would cause anybody harm, we don’t want to go back to 1990 and just have nothing for osteoporosis.”

Study shows rise of cancer in 9/11 firefighters
By Jonathan LaPook
September 1, 2011
The Lancet Medical Journal report is the first comprehensive cancer study of New York City Firefighters after 9/11. This federally funded study shows firefighters working at the site had ten percent more cancers than the general public and 19 percent more cancers than firemen not involved. In all, there were 263 cancers among almost nine thousand exposed firefighters…. "I would draw no definitive conclusion from it at this point. One wouldn't expect to see an elevation in solid tumors so early in seven year period. Usually it takes decades," said Columbia's Dr. Alfred Neugut who studies the link between environment and cancer.

Video: A Biography of Cancer

August 30, 2011
Joining me now is Dr. Siddhartha Mukherjee. He's a cancer physician and an assistant professor of medicine at Columbia. The book is called the Emperor of all Maladies; A Biography of Cancer. Drawing upon his own experiences with patients, he presents a textured portrait of this disease in its 4,000 year history.

The Annals of Extreme Surgery By Barron H. Lerner
August 30, 2011
More and more doctors are now using an extremely aggressive procedure to treat certain colorectal and ovarian cancers called Hipec, in which patients first undergo surgery to remove any visible cancer, then have heated chemotherapy pumped into the abdominal cavity for 90 minutes to kill any remaining cells….We shouldn’t be surprised by the sudden emergence of this therapy. Heated chemotherapy is the latest in a long list of very toxic treatments used by well-meaning cancer doctors who have confused doing more for patients with doing what is best for them.

Barron H. Lerner, a professor of medicine and public health at Columbia, is the author of “The Breast Cancer Wars: Hope, Fear and the Pursuit of a Cure in Twentieth-Century America” and the forthcoming “One for the Road: Drunk Driving Since 1900.”

NPR Talk of the Nation
More Not Always Better When Treating Cancer
August 30, 2011
As more doctors turn to an aggressive treatment for certain forms of cancer, Dr. Barron Lerner warns that when it comes to treating cancer, more isn't always better. … NEAL CONAN, host: Dr. Lerner is a professor of medicine and public health at Columbia University.

NPR Planet Money
When Cancer Treatments Do More Harm Than Good By Jacob Goldstein
August 30, 2011
An op-ed in today’s NYT looks at the long history of aggressive cancer treatments that became widely popular before they were proven effective. Often, studies ultimately showed those treatments were useless, or even harmful. That history continues today. The author, a Columbia med school [sic] doc named Barron Lerner, singles out a treatment that uses heated chemotherapy drugs along with surgery to treat certain colorectal and ovarian cancer patients.

The Letting Go By Siddhartha Mukherjee
August 28, 2011
Our experience of death has become disembodied. The corpus has vanished from the most corporeal of our rituals. The corpus has vanished from the most corporeal of our rituals — and we are left standing with our hands outstretched and taut but with no counterweight to bear, like the man on the riverbank holding air….Siddhartha Mukherjee is an assistant professor of medicine in the division of medical oncology at Columbia University. He is the author of "The Emperor of All Maladies: A Biography of Cancer."

Lovelorn in a Facebook Age
By Elizabeth Bernstein
August 23, 2011
I  woke up one day last week to an anguished email from a friend whose girlfriend had just broken up with him.… "It's not a heartbroken thing, it's a brain-broken thing," says Marianne Legato, a cardiologist and founder of the Partnership for Gender-Specific Medicine at Columbia University….The level of neurotransmitters in the brain are affected in a romantic split, producing a range of symptoms from sadness and anxiety to changes in sleep, appetite and even motor coordination.

‘Superfoods’ May Ward-off-diseases
August 22, 2011
Columbia University cardiologist Dr. Lori Mosca says you can find healthy ingredients to make a superfood salad.

Marriage helps survival after heart surgery
By Carina Storrs
August 22, 2011
Marriage is thought to have a number of health benefits, including greater longevity, less stress, and a lower risk of heart disease, diabetes, and depression. Now, a new study suggests you can add a better survival rate after heart surgery to the list of health perks.…It's possible that women may have less to gain from marriage because they tend to have larger support networks than men, notes Matthew M. Burg, Ph.D., associate clinical professor of medicine at Columbia University, in New York City.

PEN Literary Awards for 2011

August 11, 2011
The accolades continue for Siddhartha Mukherjee, a physician and an assistant professor of medicine at Columbia, who won a Pulitzer earlier this year and has now won the PEN/E.O. Wilson literary science writing award, also for his The Emperor of All Maladies: A Biography of Cancer (Scribner).

When extreme exercise turns deadly By Linda Carroll
August 9, 2011
The heart-related deaths of two New York City triathlon competitors has once again opened the question of whether extreme exercise can be dangerous, or even deadly...Part of the problem is the frigid water that the triathletes plunge into, said Dr. Ajay Kirtane, a cardiologist and an assistant professor of medicine at the New York-Presbyterian Hospital/Columbia Medical Center.

Telling the Story Behind Cancer
August 8, 2011
Health correspondent Betty Ann Bowser talks to Siddhartha Mukherjee, author of "The Emperor of All Maladies: A Biography of Cancer," a history of the search for ways to treat cancer and how it has been perceived…Dr. Mukherjee knows that reality well. He's an oncologist and cancer researcher at the Columbia University Medical Center in New York City.