WORMAN LAB

Welcome to the WWW Home Page of the Worman Lab

Howard J. Worman, M. D.
Departments of Medicine and of Anatomy and Cell Biology
Columbia University College of Physicians & Surgeons
New York, New York

Email: hjw14@columbia.edu

CURRENT LAB MEMBERS

• Jason Choi

• Ann-Mari Hakelein

• Angelika Ludtke

• Antoine Muchir

• Cecilia Ostlund

• Yuexia Wang

• Wei Wu

RESEARCH ACTIVITES

• Nuclear envelope and inherited diseases caused by mutations in its proteins

• Hepatitis C

• Nuclear envelope autoantibodies in primary biliary cirrhosis and primary sclerosing ‰cholangitis

SELECTED RECENT PUBLICATIONS

Lin, F., Morrison, J. M., Wu, W. and Worman, H. J. MAN1, an integral protein of the inner nuclear membrane, binds smad2 and smad3 and antagonizes transforming growth factor-beta signaling. Hum. Mol. Genet. 2005;14:437-445.

Ostlund, C., Garcia-Carrasquillo, R. M., Belayew, A and Worman, H. J. Intracellular trafficking and dynamics of double homeodomain proteins. Biochemistry 2005;22:2378-2384.

Worman, H. J. and Gundersen, G. G. Here come the SUNs: a nucelocytoplasmic missing link. Trends Cell Biol. 2006; 16:67-69.

Boguslavsky, R. L., Stewart, C. and Worman, H. J. Nuclear lamin A inhibits adipocyte differentiation: implications for Dunnigan-type familial partial lipodystrophy. Hum. Mol. Genet. 2006;15:653-663.

Ostlund, C., Sullivan, T., Stewart, C. L. and Worman, H. J. Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins. Biochemistry 2006;45:1374-1382.

Caputo, S., Couprie, J., Duband-Goulet, I., Konde., E., Lin F., Braud, S., Gondry, M., Gilquin, B., Worman, H. J. and Zinn-Justin, S. The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain. J. Biol. Chem. 2006;281:18208-18215.

Wang, Y., Herron, A. J. and Worman, H. J. Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy. Hum. Mol. Genet.2006;15:2479-2489.

Muchir, A., Massart, C., van Engelen, B. G., Lammens, M., Bonne, G. and Worman, H. J. Proteasome-mediated degradation of integral inner nuclear membrane protein emerin in fibroblasts lacking A-type lamins. Biochem. Biophys. Res. Commun. 2006;351:1011-1007.

SUPPORTED OVER THE YEARS BY

• American Cancer Society

• American Gastroenterological Association

• American Diabetes Association

• American Liver Foundation

• Blowitz-Ridgeway Foundation

• Charles E. Culpeper Foundationâ

• Charles Revson Foundation

• Crohn's & Colitis Foundation of America

• Henry M. and Lillian Stratton Foundation

• Human Frontiers Science Program

• Integrated Therapeutics Group, Inc.

• Irma T. Hirschl Trust

• March of Dimes Birth Defects Foundation

• Muscular Dystrophy Association

• National Institutes of Health

• National Science Foundation

• Silberberg Award (Columbia University)

USEFUL LINKS

• National Center for Biotechnology Information (NCBI) -- Genbank

LOCAL LINKS

• Diseases of the Liver

• World Wide Worman