Columbia University - College of Physicians and Surgeons

Dept. of Medicine | Division of Nephrology | A-Z Index

Kiryluk Lab

Selected Publications

Kiryluk K, Sanchez-Rodriguez E, Zhou XJ, et al. GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy. MedRxiv November 20, 2021. doi.org/10.1101/2021.11.19.21265383.

Liu L, Khan A, Sanchez-Rodriguez E, et al. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. MedRxiv November 20, 2021. doi.org/10.1101/2021.11.19.21265524.

Khan A, Turchin M, Patki A, et al. Genome-wide polygenic score with APOL1 risk genotypes predicts chronic kidney disease across major continental ancestries. MedRxiv October 26, 2021. doi.org/10.1101/2021.10.25.21265398.

Xu K, Shang N, Levitman A, et al. Elevated NGAL is Associated with the Severity of Kidney Injury and Poor Prognosis of Patients with COVID-19. Kidney International Reports October 7, 2021. doi.org/10.1016/j.ekir.2021.09.005. Press. More Press

Khan A, Shang N, Petukhova, et al. Medical Records-Based Genetic Studies of the Complement System. J Am Soc Nephrol. 2021:ASN.2020091371. doi: 10.1681/ASN.2020091371. Editorial

Shang N, Khan A, Polubriaginof F, et al. Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies. NPJ Digit Med. 2021;4(1):70. doi: 10.1038/s41746-021-00428-1. Press

Povysil G, Butler-Laporte G, Shang N, et al. Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19. J Clin Invest. 2021;147834. doi: 10.1172/JCI147834. Editorial

Sanchez-Rodriguez E, Southard CT, Kiryluk K. GWAS-Based Discoveries in IgA Nephropathy, Membranous Nephropathy, and Steroid Sensitive Nephrotic Syndrome. Clin J Am Soc Nephrol. 2021;16(3):485-466:doi: 10.2215/CJN.14031119

Xie J, Liu L, Mladkova N, et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nature Communications 11, 1600 (2020).

Xu D, Wang C, Kiryluk K, et al. Co-localization between Sequence Constraint and Epigenomic Information Improves Interpretation of Whole-Genome Sequencing Data. Am J Hum Genet. 2020;106(4):513-524. doi: 10.1016/j.ajhg.2020.03.003.

Zanoni F, Kiryluk K. Genetic background and transplantation outcomes: insights from genome-wide association studies. Curr Opin Organ Transplant. 2020 Feb;25(1):35-41.

Neugut YD, Mohan S, Gharavi AG, et al. Cases in Precision Medicine: APOL1 and Genetic Testing in the Evaluation of Chronic Kidney Disease and Potential Transplant Ann Intern Med. 2019. doi: 10.7326/M19-1389.

Steers NJ, Li Y, Drace Z, et al. Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection. N Engl J Med. 2019 May 16;380(20):1918-1928. Press

Kiryluk K, Goldstein DB, Rowe JW, et al. Precision Medicine in Internal Medicine. Ann Intern Med. 2019. doi: 10.7326/M18-0425. Press

Groopman EE, Marasa M, Cameron-Christie S, et al. Diagnostic Utility of Exome Sequencing for Kidney Disease. N Engl J Med. 2019;380(2):142-151. doi: 10.1056/NEJMoa1806891. Press

Verbitsky M, Westland R, Perez A, et al. The copy number variation landscape of congenital anomalies of the kidney and urinary tract. Nat Genet. 2019;51(1):117-127. doi: 10.1038/s41588-018-0281-y.

Backenroth D, He Z, Kiryluk K, et al. FUN-LDA: A latent Dirichlet allocation model for predicting tissue-specific functional effects of noncoding variation. Am J Hum Genet. 2018;102(5):920-942.

Polubriaginof FCG, Vanguri R, Quinnies K, et al. Disease Heritability Inferred from Familial Relationships Reported in Medical Records. Cell 2018. doi:https://doi.org/10.1016/j.cell.2018.04.032. Press

Kiryluk K, Bomback AS, Cheng YL, et al. Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics. Semin Nephrol. 2018 Jan;38(1):40-51. doi: 10.1016/j.semnephrol.2017.09.006.

Kiryluk K, Li Y, Moldoveanu Z, et al. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway. PLoS Genetics 2017; doi: https://doi.org/10.1371/journal.pgen.1006609.

Kiryluk K, Novak J. The Genetics and immunobiology of IgA nephropathy. J Clin Invest. 2014;124(6):2325-32.

Kiryluk K, Li Y, Scolari F, et al. Novel GWAS Loci for IgA Nephropathy Implicate the Intestinal Immunity Network. Nat Genet. 2014; 46(11):1187-96.

Kiryluk K, Novak J, Gharavi AG. Genetics of IgA Nephropathy: Insight from the Genetic Studies. Ann Rev Medicine. 2013; 64:339-56.

Kiryluk K, Li Y, Sanna-Cherchi S, et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genetics. 2012; 8(6):e1002765. News

Kiryluk K, Moldoveanu Z, Sanders TJ, et al. Aberrant glycosylation of IgA1 is inherited in pediatric Henoch-Schonlein nephritis. Kidney Int. 2011; 80(1):79-87.


For a full list of publications, please visit Pubmed