Columbia University - College of Physicians and Surgeons

Dept. of Medicine | Division of Nephrology | A-Z Index

Kiryluk Lab

Selected Publications

Kiryluk K, Sanchez-Rodriguez E, Zhou XJ, et al. GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy. MedRxiv November 20, 2021.

Liu L, Khan A, Sanchez-Rodriguez E, et al. Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits. MedRxiv November 20, 2021.

Khan A, Turchin M, Patki A, et al. Genome-wide polygenic score with APOL1 risk genotypes predicts chronic kidney disease across major continental ancestries. MedRxiv October 26, 2021.

Xu K, Shang N, Levitman A, et al. Elevated NGAL is Associated with the Severity of Kidney Injury and Poor Prognosis of Patients with COVID-19. Kidney International Reports October 7, 2021. Press. More Press

Khan A, Shang N, Petukhova, et al. Medical Records-Based Genetic Studies of the Complement System. J Am Soc Nephrol. 2021:ASN.2020091371. doi: 10.1681/ASN.2020091371. Editorial

Shang N, Khan A, Polubriaginof F, et al. Medical records-based chronic kidney disease phenotype for clinical care and “big data” observational and genetic studies. NPJ Digit Med. 2021;4(1):70. doi: 10.1038/s41746-021-00428-1. Press

Povysil G, Butler-Laporte G, Shang N, et al. Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19. J Clin Invest. 2021;147834. doi: 10.1172/JCI147834. Editorial

Sanchez-Rodriguez E, Southard CT, Kiryluk K. GWAS-Based Discoveries in IgA Nephropathy, Membranous Nephropathy, and Steroid Sensitive Nephrotic Syndrome. Clin J Am Soc Nephrol. 2021;16(3):485-466:doi: 10.2215/CJN.14031119

Xie J, Liu L, Mladkova N, et al. The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. Nature Communications 11, 1600 (2020).

Xu D, Wang C, Kiryluk K, et al. Co-localization between Sequence Constraint and Epigenomic Information Improves Interpretation of Whole-Genome Sequencing Data. Am J Hum Genet. 2020;106(4):513-524. doi: 10.1016/j.ajhg.2020.03.003.

Zanoni F, Kiryluk K. Genetic background and transplantation outcomes: insights from genome-wide association studies. Curr Opin Organ Transplant. 2020 Feb;25(1):35-41.

Neugut YD, Mohan S, Gharavi AG, et al. Cases in Precision Medicine: APOL1 and Genetic Testing in the Evaluation of Chronic Kidney Disease and Potential Transplant Ann Intern Med. 2019. doi: 10.7326/M19-1389.

Steers NJ, Li Y, Drace Z, et al. Genomic Mismatch at LIMS1 Locus and Kidney Allograft Rejection. N Engl J Med. 2019 May 16;380(20):1918-1928. Press

Kiryluk K, Goldstein DB, Rowe JW, et al. Precision Medicine in Internal Medicine. Ann Intern Med. 2019. doi: 10.7326/M18-0425. Press

Groopman EE, Marasa M, Cameron-Christie S, et al. Diagnostic Utility of Exome Sequencing for Kidney Disease. N Engl J Med. 2019;380(2):142-151. doi: 10.1056/NEJMoa1806891. Press

Verbitsky M, Westland R, Perez A, et al. The copy number variation landscape of congenital anomalies of the kidney and urinary tract. Nat Genet. 2019;51(1):117-127. doi: 10.1038/s41588-018-0281-y.

Backenroth D, He Z, Kiryluk K, et al. FUN-LDA: A latent Dirichlet allocation model for predicting tissue-specific functional effects of noncoding variation. Am J Hum Genet. 2018;102(5):920-942.

Polubriaginof FCG, Vanguri R, Quinnies K, et al. Disease Heritability Inferred from Familial Relationships Reported in Medical Records. Cell 2018. doi: Press

Kiryluk K, Bomback AS, Cheng YL, et al. Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics. Semin Nephrol. 2018 Jan;38(1):40-51. doi: 10.1016/j.semnephrol.2017.09.006.

Kiryluk K, Li Y, Moldoveanu Z, et al. GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway. PLoS Genetics 2017; doi:

Kiryluk K, Novak J. The Genetics and immunobiology of IgA nephropathy. J Clin Invest. 2014;124(6):2325-32.

Kiryluk K, Li Y, Scolari F, et al. Novel GWAS Loci for IgA Nephropathy Implicate the Intestinal Immunity Network. Nat Genet. 2014; 46(11):1187-96.

Kiryluk K, Novak J, Gharavi AG. Genetics of IgA Nephropathy: Insight from the Genetic Studies. Ann Rev Medicine. 2013; 64:339-56.

Kiryluk K, Li Y, Sanna-Cherchi S, et al. Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis. PLoS Genetics. 2012; 8(6):e1002765. News

Kiryluk K, Moldoveanu Z, Sanders TJ, et al. Aberrant glycosylation of IgA1 is inherited in pediatric Henoch-Schonlein nephritis. Kidney Int. 2011; 80(1):79-87.

For a full list of publications, please visit Pubmed