Columbia University - College of Physicians and Surgeons

Dept. of Medicine | Division of Nephrology | A-Z Index

Kiryluk Lab

About GIGA-kids Study

The GIGA-kids Study (Genomics of IgA-related disorders in kids Study) is a multicenter collaborative study based at Columbia University and sponsored by the Midwest Pediatric Nephrology Consortium (MWPNC). The study aims to recruit over 1,000 children with IgA nephropathy or Henoch-Schönlein purpura (with or without nephritis) for the purpose of genetic, genomic and biomarker studies.

IgA nephropathy represents the leading cause of kidney failure among young adults. Henoch-Schönlein purpura is a related disorder with skin manifestations that frequently leads to nephropathy in children. Our prior genetic studies suggest that patients carrying more risk alleles have an earlier onset of disease. Accordingly, GIGA-kids extends our genetic investigations to pediatric patients, aiming to validate the known disease markers and to discover new genetic and biochemical predictors of disease that may be specific to children.

GIGA-kids Investigators

Midwest Pediatric Nephrology Consortium (Clinical Sites):

Robert Wyatt, MD, Le Bonheur Children’s Hospital, Memphis, TN
Raoul Nelson, MD, University of Utah, Salt Lake City, UT

Columbia University, New York, NY (Genetics):

Krzysztof Kiryluk, MD, Columbia University, New York City, NY
Ali Gharavi, MD, Columbia University, New York City, NY

University of Alabama at Birmingham, Birmingham, AL (Biomarkers):

Jan Novak, PhD, University of Alabama at Birmingham, Birmingham, AL
Bruce Julian, MD, University of Alabama at Birmingham, Birmingham, AL

Nationwide Children’s, Columbus, OH (Data Coordinating Center):

William Smoyer, MD, Nationwide Children’s Hospital, Columbus, OH

GIGA-kids Clinical Network

Le Bonheur Children’s Hospital, Memphis, TN

Site PI: Robert Wyatt, MD

University of Utah, Salt Lake City, UT

Site PI: Raoul Nelson, MD

Nationwide Children’s Hospital, Columbus, OH

Site PI: William Smoyer, MD

Columbia University, New York City, NY

Site PI: Lin Fangming, MD

Cornell University, New York City, NY

Site PI: Oleh Akchurin, MD

Stony Brook Children’s Hospital, Stony Brook, NY

Site PI: Robert Woroniecki, MD, and Katarina Supe-Markovina, MD

Children's Hospital New Orleans, LSU Health Sciences Center, LA

Site PI: Diego H. Aviles, MD

Texas Tech University Health Sciences Center, Amarillo, TX

Site PI: Tetyana Vasylyeva, MD

Mott Children’s Hospital, Ann Arbor, MI

Site PI: David Selewski, MD

Helen DeVos Children’s Hospital, Grand Rapids, MI

Site PI: Alejandro Quiroga, MD

Texas Children’s Hospital, Houston, TX

Site PI: Scott Wenderfer, MD, and Ewa Elenberg, MD

University of Minnesota, Minneapolis, MN

Site PI: Michelle Rheault, MD

St. Louis Children's Hospital, St. Louis, MO

Site PI: Keefe Thomas Davis, MD, and Michael Seifert, MD

SUNY Buffalo, Buffalo, NY

Site PI: Mahmoud Kallash, MD

East Carolina University, Greenville, NC

Site PI: Guillermo Hidalgo, MD

Cincinnati Children's Hospital, Cincinnati, OH

Site PI: Donna Claes, MD

Seattle Children's Hospital, Seattle, WA

Site PI: Joseph T. Flynn, MD

Lurie Children's Hospital, Northwestern University, Chicago, IL

Site PI: Margaret E. Bock, MD

Connecticut Children's Medical Center, Hartford, CT

Site PI: Cynthia Silva, MD, and Sherene Mason, MD

Medical University of South Carolina, Charleston, SC

Site PI: Katherine E. Twombley, MD

Mattel Children's Hospital UCLA, Los Angeles, CA

Site PI: Dr. Patricia Weng, MD

Children's Hospital of Richmond at VCU, Richmond, Virginia

Site PI: Dr. Nianzhou Xiao, MD

University of Texas Health Science Center, San Antonio, TX

Site PI: Dr. Daniel Ranch, MD

Miller School of Medicine, Holtz Children's Hospital, Miami, FL

Site PI: Carolyn Abitbol, MD

University Of Alberta, Stollery Children's Hospital, Edmonton, CA

Site PI: Abdullah AlAbbas, MD

University Of Kentucky, Lexington, KY

Site PI: Aftab S. Chishti, MD

New York Medical College, Valhalla, NY

Site PI: Dmitry Samsonov, MD and Robyn Matloff, MD

Driscoll Children's Hospital, Corpus Christi, TX

Site PI: Samhar Al-AKash, MD

Medical College of Milwaukee, Wisconsin, WI

Site PI: Raji Sreedharan, MD

Phoenix Children's Hospital, Phoenix, AZ

Site PI: Frana Iorember, MD

...additional sites pending confirmation

GIGA-Europe Network

GIGA-Europe Network

Mirrors the US-based GIGA-kids network and opens our studies to European nephrology centers. The network consists of centers in Italy, Poland, France, Germany, Sweden, the Netherlands, Croatia, Czech Republic, Hungary, Turkey and the UK.